1/13/2024 0 Comments Transtype programming![]() While it was previously believed that oesophageal cells were developed from the transdifferentiation of smooth muscle cells, that has been shown to be false. In the pancreas, it has been demonstrated that alpha cells can spontaneously switch fate and transdifferentiate into beta cells in both healthy and diabetic human and mouse pancreatic islets. Vincenzo Colucci described this phenomenon in 1891 and Gustav Wolff described the same thing in 1894 the priority issue is examined in Holland (2021). In newts when the eye lens is removed, pigmented epithelial cells de-differentiate and then redifferentiate into the lens cells. Rather, cells dedifferentiate and then redifferentiate into the cell type of interest. The only known instances where adult cells change directly from one lineage to another occurs in the species Turritopsis dohrnii (which is also known as the immortal jellyfish) and Turritopsis Nutricula (the protozoan which makes the immortal jellyfish immortal). Forcing mouse embryonic fibroblasts to express MyoD was found to be sufficient to turn those cells into myoblasts. 1987 reported the first instance (sight) of transdifferentiation where a cell changed from one adult cell type to another. The term 'transdifferentiation' was originally coined by Selman and Kafatos in 1974 to describe a change in cell properties as cuticle producing cells became salt-secreting cells in silk moths undergoing metamorphosis. Current uses of transdifferentiation include disease modeling and drug discovery and in the future may include gene therapy and regenerative medicine. It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Transdifferentiation, also known as lineage reprogramming, is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. ![]() ( February 2015) ( Learn how and when to remove this template message) Please help improve it to make it understandable to non-experts, without removing the technical details. This article may be too technical for most readers to understand.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |